Rosmarinic acid is structurally an ester of caffeic acid, and is one of the flavor substances of many aromatic plants such as rosemary (Rosmarimas officinalis), perilla (Perilla fratescens) and melissa officinalis one. rosmarinic acid extraction from rosemary is the normally way at bulk production.
Physical and chemical properties
Rosmarinic acid is soluble in water, methanol and ethanol, but insoluble in ethyl acetate, chloroform and petroleum ether. The CAS number of rosmarinic acid is 20283-92-5.
Safety management
The "Announcement on the List of Names of Cosmetic Raw Materials Used" issued by China's State Food and Drug Administration in 2014, CTFA and the "Chinese Name Catalog of International Cosmetic Raw Materials Standards" published by CTFA and China Fragrance Association in 2010 all use rosmarinic acid as a cosmetic raw material , there is no report that it is unsafe for external use.
Application in cosmetics
Rosmarinic acid extract has antibacterial properties. When the concentration is 0.5mg/mL, the inhibition rate to Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and other microorganisms is 100%; the MIC to Propionibacterium acnes is 0.003μg/mL.
1. Rosmarinic acid has antibacterial and fungal activity, and it can prevent the formation and accumulation of dental plaque when used in tooth cleaning products; the level of ICAM-1 (intercellular adhesion molecule-1) can be used as an indicator to evaluate the state of periodontal inflammation An indicator, rosmarinic acid can inhibit this, combined with its antibacterial properties, it is effective in the prevention and treatment of periodontitis;
2. rosemary extract supplement Rosmarinic acid has anti-inflammatory effect. It is a non-steroidal anti-inflammatory agent, and its efficacy is several times that of commonly used anti-inflammatory agents. It can treat and prevent rosacea and other diseases;
3. Rosmarinic acid is strongly absorbed in the ultraviolet B area, has anti-sun function, and prevents the deepening of skin color; the reduction and absence of filigrin may be the main cause of dry skin diseases such as atopic dermatitis, and it is confusing. Marinic acid can promote the formation of fibroin, combined with its inhibition of hyaluronidase activity, it shows that it has moisturizing effect; Rosemary extract ingredients rosmarinic acid has anti-oxidation and anti-aging functions.
